With quotes from major figureheads like Thomas Jefferson, George W. Bush and Osama Bin Laden, Bill Maher, with a Jewish-Catholic background, sets out to prove that having faith and seeking directions from God is basically ridiculous and may be due to a neurotic disorder. Interviewing Christians, Catholics, Jews, Muslims, Mormons, scientists, gays, and atheists, he cites that the number of non-believers is increasing in North America. He attempts to prove his point by citing inconsistencies in the Bible, the controversial birth of Lord Jesus, the inability of religious heads to account for His absence for over 18 years, as well as the absence of any concrete evidence that disproves the theory of evolution.