Fifteen years ago, director Noah Hutton got fascinated by a promising scientific project led by Henry Markam. The expression ‘in silico’ means something is carried out via a computer or a computer simulation. Markam claimed he could replicate the human brain in all its complexity on a supercomputer, in just one decade. This would mean a revolution in terms of treating Alzheimer and other neurological diseases. During ten years, Hutton documents the audacious project, where a promising plan increasingly seems to fade into mere hubristic ambition.